CICO: Consortium for Integrative Computational Oncology at USC

CICO Members

LeadershipAffiliated Members (ClinicalExperimentalModeling)

Leadership

Paul Macklin

Paul Macklin, Ph.D., Co-Director, Co-Founder

Affiliations & Appointments

  • Assistant Professor, Center for Applied Molecular Medicine, Keck School of Medicine of USC

Education

Research Interests

Dr. Macklin develops discrete and continuum multiscale models of cancer and treatment, calibration methods for patient-specific simulations, and multidisciplinary integrative workflows. In his decade of cancer research, Macklin has worked closely with pathologists, radiologists, surgeons, biologists, mathematicians and engineers in exciting, multidisciplinary teams.

Research & Contact Information

MathCancer.org

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Paul Macklin

Paul Newton, Ph.D., Co-Director, Co-Founder

Affiliations & Appointments

  • Professor, Dept. of Aerospace and Mechanical Engineering, Viterbi School of Engineering, USC
  • Professor, Dept. of Mathematics, Dornsife College of Letters, Arts & Sciences, USC

Education

Research Interests

Professor Newton develops mathematical and computational models for simulating and understanding all aspects of the metastatic process in patients. He uses techniques such as Markov chain Monte Carlo methods (MCMC) for statistical simulations of cancer progression, computational fluid dynamic (CFD) simulations of the 'fluid phase' of cancer involving the simulation of circulating tumor cells (CTCs) in the blood stream and lymphatic system, and 'active shape models' (ASMs) for developing models for the mechanical properties of cancer cells. He works closely with cancer biologists, oncologists, and biomedical engineers at The Scripps Research Institute, Oregon Health & Science University, and USC.

Research & Contact Information

http://ae-www.usc.edu/personnel/newton/

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Affiliated Members

Clinical

David B. Agus, M.D.   University of Southern California
Dr. Agus, author of the New York Times bestseller "The End of Illness", is Director of the USC Center for Applied Molecular Medicine and the USC Westside Prostate Cancer Center, and is a key leader in the USC Physical Sciences Oncology Center. His research spans from clinical trials to proteomics to multidisciplinary cancer research.

Experimental

Shannon Mumenthaler, Ph.D.   University of Southern California
Dr. Mumenthaler is a biologist at the Center for Applied Molecular Medicine, who combines approaches from cell biology with approaches from the physical sciences to develop tools to interrogate the impact of microenvironmental selection pressures on tumor development. Working closely with mathematicians, clinicians, and engineers, she strives to integrate in vitro and in vivo quantitative measurements with computational tools to (1) gain a better understanding of the fundamental physical and biological processes involved in cancer progression, and (2) determine optimal treatment strategies to improve progression-free survival times in the clinic.

Modeling